Lessons learned from functional assessment of pluripotency-associated transcription factors during early embryogenesis and embryonic stem cells

Autores

  • Priscila Germany Corrêa da Silva Universidade Federal Rural de Pernambuco
  • Marcelo Tigre Moura Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • Ludymila Furtado Cantanhêde Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • José Carlos Ferreira-Silva Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • Pábola Santos Nascimento Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • Roberta Lane de Oliveira Silva Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • José Pompeu dos Santos Filho Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.
  • Marcos Antonio Lemos Oliveira Universidade Federal Rural de Pernambuco, Recife-PE, Brasil.

DOI:

https://doi.org/10.26605/medvet-n3-1796

Palavras-chave:

embryology, pluripotent, preimplantation development, totipotency

Resumo

Pluripotency-associated transcription factors (PATF) play significant roles during early embryogenesis and in embryonic stem (ES) cells, such as control of cell-cycle progression, modulation of cellular metabolism, and transcriptional control of differentiation-inducing factors. The review aims to describe the current understanding of how these PATFs contribute to the early embryo and the ES-cell phenotypes. By a selection of representative examples of such PATFs, their roles are described, and some interesting questions are presented concerning their activity in pluripotent cells which have yet to be addressed.

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31-12-2017

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da Silva, P. G. C., Tigre Moura, M., Cantanhêde, L. F., Ferreira-Silva, J. C., Nascimento, P. S., Silva, R. L. de O., dos Santos Filho, J. P., & Lemos Oliveira, M. A. (2017). Lessons learned from functional assessment of pluripotency-associated transcription factors during early embryogenesis and embryonic stem cells. Medicina Veterinária, 11(3), 210–221. https://doi.org/10.26605/medvet-n3-1796

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v. 11 n. 3 (2017)

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Reprodução Animal

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