Doença de Glässer: Uma revisão

Autores

  • Guilherme Arruda Cezar Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Recife-PE, Brasil
  • Clara Nilce Barbosa Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Recife-PE, Brasil
  • Nelson Morés Laboratório de Sanidade e Genética Animal, Embrapa Suínos e Aves, Concórdia, Santa Catarina, Brasil.

DOI:

https://doi.org/10.26605/medvet-v13n1-2604

Palavras-chave:

Haemophilus parasuis, bactéria, diagnóstico, epidemiologia, suíno.

Resumo

Haemophilus parasuis é o agente etiológico da doença de Glässer e causa graves prejuízos econômicos na indústria suína.  O diagnóstico da doença é baseado na associação do histórico clínico do rebanho, isolamento da bactéria e sorotipagem. O difícil controle do agente e das co-infecções tornam-se imprescindível o uso de tratamentos estratégicos e programas vacinais, conjugados com boas práticas de manejo. Esta revisão apresenta uma abordagem geral da Doença de Glässer e discute os aspectos epidemiológicos, diagnóstico, imunidade, prevenção e controle.

Downloads

Não há dados estatísticos.

Referências

Angen, O.; Simone, O.; Ahrens, P.; Svensmark, B.; e Leser, T.D. Development of an improved species specific PCR test for detection of Haemophilus parasuis. Veterinary Microbiology, 119 (2-4): 266-276. 2007. Aragon, V.; Segalés, J.; Oliveira S. 2012. Glässer’s Disease. In: Zimmerman J.J.; Karriker L.A.; Ramirez A.; Schwartz K.J.; Stevenson G.W. (eds), Diseases of swine. 10a ed., Iowa WileyBlackwell, 2012. p. 760-769. Bello-Orti, B.; Costa-Hurtado, M.; MartinezMoliner, V.; Segalés, J.; Aragon, V. Time course Haemophilus parasuis infection reveals pathological differences between virulent and non-virulent strains in the respiratory tract. Veterinary Microbiology, 170(3-4): 430-437, 2014.

Biberstein, E.L.; White, D.C. A proposal for the establishment of two new Haemophilus parasuis. Journal of Medical Microbiology, 2(1): 75-78. 1969. Blanco, I.; Galina-Pantoja, L.; Oliveira, S.; Pijoan, S.; Sánchez, C.; Canals, A. Comparison between Haemophilus parasuis infection in colostrums-deprived and sow-reared piglets. Veterinary Microbiology, 103 (1-2): 21-27, 2004.

Bouchet, B.; Vanier, G.; Jacques M.; Auger, E.; Gottschalk, M. Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: limited role of LOS in apoptosis and pro-inflammatory cytokine release. Microbial Pathogenesis, 46 (2): 108-113, 2009.

Cai, X.; Chen, H.; Blackall, P.J.; Yin, Z.; Wang, L.; Liu, Z.; Jin, M. Serological characterization of Haemophilus parasuis isolates from China. Veterinary Microbiology, 111 (3-4): 231236, 2005.

Cao, Q.; Feng, F.; Wang, H.; Xu, X.; Chen, H.; Cai, X. Haemophilus parasuis CPxRA twocomponente system confers bacterial tolerance to environmental stress and macrolide resistance. Microbiological Research, 206: 177-185, 2018.

Castilla, K. S.; Gobbi, D.D.S.; Moreno, L.Z.; Paixão, R.; Coutinho, T.A.; Santos J.L.; Moreno A.M. Characterization of Haemophilus parasuis isolated from Brazilian swine through serotyping, AFLP e PFGE. Research Veterinary Science, 92 (3): 366371, 2012.

Cerdà-Cuéllar, M.; Naranjo, J.F.; Verge, A.; Nofrarías, M.; Cortey, M.; Olvera, A.; Segalés, J.; Aragon, V. Sow vaccination modulates the colonization of piglets by Haemophilus parasuis. Veterinary Microbiology, 145 (3-4): 315-320, 2010.

Costa-Hurtado, M.; Aragon, V. Advances in the quest for virulence factors of Haemophilus parasuis. Veterinary Journal, 198(3): 571576, 2013.

De La Puente Redondo, V.A.; Navas-Méndez, J.; García del Blanco, N.; Ladrón-Boronat, N.; Gutiérrez-Martín, C.; Rodríguez-Ferri, E.F. Typing of Haemophilus parasuis strains by PCR-RFLP analysis of the tbpA gene. Veterinary Microbiology, 92 (3): 253-262, 2003.

Del Río, M.L.; Gutiérrez, C.B.; Rodriguez-Ferri, E.F. Value of indirect hemagglutination and coagglutination tests for serotyping Haemophilus parasuis. Journal of Clinical Microbiology, 41 (2): 880-882, 2003a.

Del Río, M.L.; Gutiérrez, B.; Gutiérrez, C.B.; Monter, J.L.; Rodríguez-Ferri, E.F.; Evaluation of survival of Actinobacillus pleuropneumoniae and Haemophilus parasuis in four liquid media and two swab specimen transport systems. American Journal of Veterinary Research, 64 (9): 1176-1180, 2003b.

Del Río, M.L.; Navas-Mendez, J.; GutiérrezMartin, C.B.; Rodriguez-Barbosa, J.I.; Rodríguez-Ferri, E.F. Identification of sulI allele of dihydropteroate synthase by representational difference analysis in Haemophilus parasuis serovar 2. Letter in Applied Microbiology, 40 (6): 436-442, 2005.

Del Río, M.L.; Navas J.; Martín A.; Gutiérrez C.; Rodríguez-Barbosa, J.; Rodríguez-Ferri, E. F. Molecular characterization of Haemophilus parasuis ferric hydroxamate uptake (fhu) genes and constitutive expression of the Fhua receptor. Veterinary Research, 37(1): 49-59, 2006.

Frandoloso, R.; Pivato, M.; Martínez-Martínez, S.; Rodríguez-Ferri, E.F.; Kreutz, L.C.; Gutierrez-Martín, C.B. Differences in Haemophilus parasuis adherence to and invasion of AOC-45 porcine aorta endothelial cells. BMC. Veterinary Research, 9(1): 207, 2013.

Hu, M.; Zhang, Y.; Xie, F.; Li, G.; Li, J.; Si, W.; Liu, S.; Hu, S.; Zhang, Z.; Shen, N.; Wang, C. Protection of piglets by a Haemophilus parasuis ghost vaccine against homologus challenge. Clinical and Vaccine Immunology, 20(6): 795-802, 2013.

Huisheng, L.; Qiao, X.; Qiaoying, Z.; Zhanqin, Z.; Haemophilus parasuis vaccines. Veterinary Immunology and Imunopathology, 180: 5358, 2016. Jia, A., Zhou, R.; Fan, H.; Yang, K.; Zhang, J.; Xu,Y.; Wang, G.; Liao, M., Development of serotype-specific PCR assays for typing Haemophilus parasuis, circulating in southern China. Journal of. Clinical. Microbiology, 55(10): 1-23, 2017.

Jin, H.; Wan, Y.; Zhou, R., Li, L.; Luo, R.; Zhang, S.; Hu, J.; Langford, P.R.; Chen, H. Identification of genes transcribed by Haemophilus parasuis in necrotic porcine lung through the selective capture of transcribed sequences (SCOTS). Environmental Microbiology, 10(12): 33263336, 2008.

Jung, K.; Ha, Y.; Kim, S.; Chae, C. Development of polymerase chain reaction and comparison with in situ hybridization for the detection of Haemophilus parasuis in formalin-fixed, paraffin-embedded tissues. Journal of Veterinary Medical Science, 66(7): 841-845, 2004.

Karriker, L.A.; Coetzee, J.; Friedship, R.M.; Prescott, J.F. Drug pharmacology, therapy, and prophylaxis. In: Zimmerman, J.J.; Karriker L.A.; Ramirez A.; Schwartz K.J.; Stevenson G.W. Diseases of swine. 10a ed. Iowa,Wiley-Blackwell, 2012. p. 106-118.

Kavanová, L.; Matiasková, K.; Levá, L.; Nedbalcová, K.; Matiasovic, J.; Faldyna, M.; Salát, J. Concurrent infection of monocytederived macrophages with porcine reproductive and respiratory syndrome virus and Haemophilus parasuis: A role of IFNα in pathogenesis of co-infection. Veterinary Microbiology, 225: 64-71, 2018.

Kielstein, P.; Rapp-Gabrielson, V.J. Designation of 15 serovars of Haemophilus parasuis on the basis of immunodifusion using heat-stable antigen extracts. Journal of Clinical Microbiology, 30(4): 862-865, 1992 Kim, J.; Chung, K.; Jung, T.; Cho, W.; Choi, C.; Chae, C. Postweaning multisystemic wasting syndrome of pigs in Korea: prevalence, microscopic lesions, and coexisting microorganisms. Journal of Veterinary Medical Science, 64(1):57-62, 2002.

Li, J.; Jiang, P.; Wang, Y.; Li, Y.; Chen, W.; Wang, X.; Li, P. Genotyping of Haemophilus parasuis from diseased pigs in China and prevalence of two coexisting virus pathogens. Preventive Veterinary Medicine, 91(2-4): 274-279, 2009.

Li, J.; Jiang, P.; Yuan, X.; Xu, L.; Kang, L.; Jiang, J.; Wang, Y. Efficient construction of Haemophilus parasuis mutants based on natural transformation. Canadian Journal of Veterinary Research, 80(4):281-286, 2016.

Lichtensteiger, C.A.; Vimr, E.R. Neuroaminidase (sialidase) activity of Haemophilus parasuis. FEMS Microbiology Letters, 152(2), 1997.

Lin, W.; Shih, H.; Lin, C.; Yang, C.; Chang, Y.; Lin, C.; Chiou, M. Molecular serotyping of Haemophilus parasuis isolated from diseased pigs and the relationship between serovars and pathological patterns in Taiwan. PeerJ Journal, 29(6): 1-17, 2018.

Liu, S.; Li,W.; Wang,Y.; Gu, C.; Liu, X.; Charreyre, C.; Fan,S.; He, Q. Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine Circovirus type 2 piglets. Virology Journal, 14: 227, 2017.

Little, T.W. Haemophilus infection in pigs. Veterinary Record, 87(14): 399-402, 1970.

Macedo, N.R.; Oliveira, S. R.; Lage, A.P.; Guedes, R.M.C. Epidemiologia molecular do Haemophilus Parasuis. Ciência Rural, 39(8): 2576-2582. 2009.

Macedo, N.R. Effect of enrofloxacin in the carrier stage of Haemophilus parasuis in naturally colonized pigs. Canadian Journal of Veterinary Research, 78(1): 17-22, 2014.

Martín de La Fuente, A.J.; Tucker, A.W.; Navas, J.; Blanco, M.; Morris, S.J.; Gutiérrez-Martín, C.B. Antimicrobial susceptibility patterns of Haemophilus parasuis from pigs in the United Kingdom and Spain. Veterinary Microbiology, 120(1-2): 184-191, 2007.

Martín de La Fuente, AJ.; Gutiérrez Martín, CB.; Pérez Martínez, C.; García Iglesias, MJ.; Tejerina, F.; Rodríguez Ferri, EF.; Effect of different vaccine formulations on the development of Glässer’s disease induced in pigs by experimental Haemophilus parasuis infection. Journal of Comparative Pathology, 140(2-3): 169-176, 2009.

Metcalf, D.S.; Maclnnes, J.I. Differential expression of Haemophilus parasuis genes in response to iron restriction and cerebrospinal fluid. Canadian Journal of Veterinary Research, 71(3): 181-188, 2007.

Morés, M.A.Z.; Oliveira Filho, J.X.; Rebelatto, R.; Klein, C.S.; Barcellos, D.E.N.; Coldebella, A.; Morés, N. Aspectos patológicos e microbiológicos das doenças respiratórias em suínos de terminação no Brasil. Pesquisa Veterinária Brasileira, 35(8):725-733, 2015.

Morozumi, T.; Nicolet, J. Morphological variation of Haemophilus parauis strains. Journal of Clinical Microbiology, 23(1): 138-142, 1986.

Moxley, R.A. Edema disease. Veterinary Clinics of North America: Food Animal Practice, 16(1): 175-185, 2000.

Narita, M.; Kawashima, K.; Matsura, S.; Uchimura, A.; Miura, Y. Pneumonia in pigs infected with pseudorabies virus and Haemophilus parasuis serovar 4. Journal of Comparative Pathology, 110(4): 329-339, 1994.

Nielsen R. Pathogenicity and immunity studies of Haemophilus parasuis serotypes. Acta Veterinaria Scandinavica, 34(2): 193-198, 1993.

Nielsen, R.; Danielsen,V. An outbreak of Glässer’s disease. Studies on etiology, serology and effects of vaccination. Nordisk Veterinaermedicin, 27: 20-25, 1975.

Oliveira Filho, J. X.; Morés, M.A.Z.; Rebelatto R.; Agnol A.M.D.; Pileski C.L.A.; Klein C.S.; Barcellos, D.E.S.N.; Morés, N. Pasteurella multocida type A as the primary agent of pneumonia and septicemia in pigs. Pesquisa Veterinária Brasileira, 35(8): 716-724, 2015.

Oliveira, S.; Galina, L.; Pijoan C. Development of a PCR test to diagnose Haemophilus parasuis infections. Journal of Veterinary Diagnostic Investigation, 13(6): 495-501. 2001.

Oliveira, S.; Blackall, P.J.; Pijoan, C. Characterization of the diversity of Haemophilus parasuis field isolates by use of serotyping and genotyping. American Journal of Veterinary Research, 64(4): 435442, 2003.

Oliveira, S. Haemophilus parasuis diagnostics. Journal of Swine Health and Production, 15(2): 99-103, 2007.

Olvera, A.; Cerdà-Cuéllar, M.; Nofrarías, M.; Revilla, E.; Segalés, J.; Aragon, V. Dynamics of Haemophilus parasuis genotypes in a farm recovered from an outbreak of Glässer’s disease. Veterinary Microbiology, 123(1-3): 230-237, 2007.

Olvera, A.; Ballester, M.; Nofrarías, M.; Sibila, M.; Aragon, V. Differences in phagocytosis susceptibility in Haemophilus parasuis strains. Veterinary Research, 40(3): 24-40, 2009.

Olvera, A.; Pina, S.; Macedo, N.; Oliveira, S.; Aragon, V.; Bensaid, A. Identification of potentially virulent strains of Haemophilus parasuis using a multiplex PCR for virulenceassociated autotransporters (vitA). Veterinary Journal, 191(2): 213-218, 2012.

Peet, R.L.; Fry, J.; Lloyd, J.; Henderson, J.; Curran, J.; Moir, D. Haemophilus parasuis septicemia in pigs. Australian Veterinary Journal, 60 (6):187, 1983.

Rafiee, M.; Bara, M.; Stephens, C.P.; Blackall, P.J. Application of ERIC-PCR for the comparison of isolates Haemophilus parasuis. Australian Veterinary Journal, 78(12): 846-849, 2000.

Rapp-Garielson, V.J.; Gabrielson, D.A. Prevalence of Haemophilus parasuis serovars among isolates from swine. American Journal of Veterinary Research, 53(5): 659-664, 1992.

Rapp-Gabrielson, V.J.; Gabrielson, D.A.; Schamber, G.J. Comparative virulence of Haemophilus parasuis serovars 1 to 7 in guinea pigs. American Journal of Veterinary Research, 53(6): 987-994, 1992.

Rapp-Gabirelson, V.J.; Kocur. G.J.; Clark, J.T.; Muir, S.K. Haemophilus parasuis: immunity in swine after vaccination. Veterinarni Medicina, 92(1): 83-90, 1997.

Rodríguez-Ferri, E.F.; Martínez, S.; Frandoloso, R.; Yubero, S.; Gutiérrez-Martín, C.B. Comparative efficacy of several disinfectants in suspension and carrier tests against Haemophilus parasuis serovars 1 and 5. Research in Veterinary Science, 88(3): 385389, 2010.

Ruiz, A.; Oliveira, S.; Torremorel, M.; Pijoan C. Outer membrane proteins and DNA profiles in strains of Haemophilus parasuis recovered from systemic and respiratory sites. Journal of Clinical Microbiology, 39(5): 1757-1762, 2001.

Sack, M.; Baltes, N. Identification of novel potential virulence-associated factors in Haemophilus parasuis. Veterinary Microbiology, 136(3-4):382-386, 2009.

Segalés, J.; Domingo, M.; Solano, G.I.; Pijoan C. Immunohistochemical detection of Haemophilus parasuis serovar 5 in formalinfixed, paraffin-embedded tissues of experimentally infected swine. Journal of Veterinary Diagnostic Investigation, 9(3):237-243, 1997.

Smart, N.L.; Miniats, O.P.; Rosendal, S.; Friendship, M. Glässer’s disease and prevalence of subclinical infection with Haemophilus parasuis in southern Ontario. Canadian Journal of Veterinary Research, 4(53): 339-343, 1989.

Solano-Aguilar, G.I.; Pijoan, C.; Rapp-Gabrielson, V.; Collins, J.; Carvalho, L.F.; Winkelman, N. Protective role of maternal antibodies against Haemophilus parasuis infection. American Journal of Veterinary Research, 60(1): 8187, 1999.

Tadjine, M.; Mittal, K.R.; Bourdon, S.; Gottscalk, M. Development of a new serological test for serotyping Haemophilus parasuis isolates and determination of their prevalence in North America. Journal Clinical Microbiology, 42(2): 839-840, 2004.

Takahashi, K.; Nagai, S.; Yagihashi, T.; Ikehata, T.; Nakano, Y.; Senna, K.; Maruyama, T.; Murofushi, J. A cross-protection experiment in pigs vaccinated with Haemophilus parasuis serovars 2 and 5 bacterins, and evaluation of a bivalent vaccine under laboratory and field condition. Journal of Veterinary Medical Science, 63(5): 487-491, 2001.

Thacker, E.L.; Minion, F.C. Mycoplasmosis. In: Zimmerman, J.J.; Karriker, L.A.; Ramirez, A.; Schwartz, K.J.; Stevenson, G.W. Diseases of swine. 10a ed., Iowa, Wiley-Blackwell, 2012. p.779-797.

Turni, C.; Blackall, P.J. Comparison of the indirect haemagglutination and gel diffusion test for serotyping Haemophilus parasuis. Veterinary Microbiology, 106(1-2): 145151, 2005.

Turni, C.; Blackall, P.J. Comparison of sampling sites and detection methods for Haemophilus parasuis. Australian Veterinary Journal, 85(5): 177-184, 2007.

Turni, C.; Pyke, M.; Blackall, P.J. Validation of a real-time PCR for Haemophilus parasuis. Journal of Applied Microbiology, 108(4): 1323-1331, 2010.

Valhe, J.L.; Haynes, J.S.; Andrews, J.J. Experimental reproduction of Haemophilus parasuis infection in swine: clinical, bacteriological, and morphological findings. Journal of Veterinary. Diagnostic Investigation, 7(4): 476-480, 1995.

Valhe, J.L.; Haynes, J.S.; Andrews, J.J.; Interaction of Haemophilus parasuis with nasal and tracheal mucosa following intranasal inoculation of cesarean derived colostrums deprived (CDCD) swine. Canadian Journal of Veterinary Research, 61(3):200-206, 1997.

Van Reeth, K.; Brown, I.H.; Olsen, C.W. Influenza virus. In: Zimmerman, J.J.; Karriker, L.A.; Ramirez, A.; Schwartz, K.J.; Stevenson, G.W. Diseases of swine. 10a ed., Iowa. WileyBlackwell, 2012. p. 557-571.

Vengust, G.; Valencak, Z.; Bidovec, A. A serological survey of selected pathogens in wild boar in Slovenia. Journal of Veterinary Medicine, 53(1): 24-27, 2006.

Xue, Q.; Zhao, Z.; Liu, H.; Chen, K.; Xue, Y.; Wang, L. First comparison of adjuvant for trivalent inactivated Haemophilus parasuis serovars 4, 5 and 12 vaccines against Glässer’s disease. Veterinary Immunology and Immunopathology, 168 (3-4): 153-158, 2014.

Yue, M.; Yang, F.; Yang, J.; Bei, W.; Cai, X.; Chen, L.; Dong, J.; Zhou, R.; Jin, M.; Jin, Q.; Chen, H. Complete genome sequence of Haemophilus parasuis SH0165. Journal of Bacteriology, 191(4): 359-360, 2009.

Zhao, L.; Gao, X.; Liu, C.; Lv, X.; Jiang, N.; Zheng, S. Deletion of the vacJ gene affects the biology and virulence in Haemophilus parasuis serovar 5. Gene, 603(1): 42-53, 2016.

Zhao, Y.; Wang, Q.; Li, J.; Lin, X.; Huang, X.; Fang, B. Epidemiology of Haemophilus parasuis isolates from pigs in China using serotyping, antimicrobial susceptibility, biofilm formation and ERIC-PCR genotyping. PeerJ Journal, 13(6):1-16, 2018.

Zhou, X.; Xu, X.; Zhao, Y.; Chen, P.; Zhang, X.; Chen, H.; Cai, X. Distribution of antimicrobial resistance among different serovars of Haemophilus parasuis isolates. Veterinary Microbiology, 141(1-2): 168-173, 2010.

Downloads

Publicado

09-09-2019

Como Citar

Cezar, G. A., Barbosa, C. N., & Morés, N. (2019). Doença de Glässer: Uma revisão. Medicina Veterinária, 13(1), 14–26. https://doi.org/10.26605/medvet-v13n1-2604

Edição

Seção

Clínica e cirurgia de grandes animais