INFLUÊNCIA DE METAIS NO COMPORTAMENTO REPRODUTIVO DE PEIXES, REVISÃO BIBLIOGRÁFICA.
Palavras-chave:
Metals Endocrine disrupters Toxicity, Reproductive system, Water contamination,Resumo
Metais pesados são contaminantes aquáticos comuns, liberados na biota aquática por diversas fontes. Tal contaminação causa preocupação devido ao fato da remoção incompleta destes poluentes pelos atuais sistemas de potabilidade de água, além do risco que representam para os organismos aquáticos. Entretanto, grande parte dos autores direciona seus estudos para a avalição neurotóxica destes compostos. O objetivo do presente estudo foi avaliar as informações disponíveis na literatura científica a cerca dos efeitos dos metais no sistema reprodutor de peixes. Observou-se uma predominância de estudos relatando efeitos no sistema reprodutor de peixes expostos a concentrações abaixo ou iguais às estabelecidas pela legislação brasileira, ressaltando a importância de monitorar e controlar a composição dos descartes domésticos e industriais. Embora os estudos aqui relatados tratem de exposições laboratoriais, os dados são plenamente transponíveis para o ambiente natural, onde alterações reprodutivas podem implicar em complicações na continuidade das gerações dos peixes, impactando em todo ecossistema.Downloads
Referências
ACOSTA, I.B.; JUNIOR, A.S.V.; SILVA, E.F.; CARDOSO, T.F.; CALDAS, J.S.; JARDIM, R.D.; CORCINI, C.D. Effects of exposure to cadmium in sperm cells of zebrafish, Danio rerio. Toxicology Reports, v. 3, p. 696- 700, 2016.
ALAHABADI, A.; MALVANDI, H. Contamination and ecological risk assessment of heavy metals and metalloids in surface sediments of the Tajan River, Iran. Marine Pollution Bulletin, v. 133, p. 741- 749, 2018.
ALTENHOFEN, S.; WIPRICH, M.T.; NERY, L.R.; LEITE, C.E.; VIANNA,M.R.M.R.; BONAN, C.D. Manganese(II) chloride alters behavioral and neurochemical parameters in larvae and adult zebrafish. Aquatic Toxicology, v. 182, p. 172- 183, 2017.
ATLI, G.; ARIYUREK, S.Y.; KANAK, E.G.; CANLI, M. Alterations in the serum biomarkers belonging to different metabolicsystems of fish (Oreochromis niloticus) after Cd and Pb exposures. Environmental Toxicology and Pharmacology, v. 40, p. 508- 515, 2015.
BARILLET, S.; LARNO, V.; FLORIANI, M.; DEVAUX, A.; ADAM- GUILLERMIN, C. Ultrastructural effects on gill, muscle, and gonadal tissues induced in zebrafish (Danio rerio) by a waterborne uranium exposure. Aquatic Toxicology, v. 100, p. 295-302, 2010.
BRITO, I.A.; GARCIA, J.R.E.; SALAROLI, A.B.; FIGUEIRA, R.C.L.; MARTINS, C.C.; NETO, A.C.; GUSSO- CHOUERI, P.K.; CHOURERI, R.B.; ARAUJO, S.B.L.; RIBEIRO, C.A.O. Embryo toxicity assay in the fish species Rhamdia quelen (Teleostei, Heptaridae) to assess water quality in the Upper Iguaçu basin (Parana, Brazil). Chemosphere, v. 208, p. 207-218, 2018.
BRASIL. Conselho Nacional do Meio Ambiente – CONAMA, 2005 [viewed 25 November 2014]. Resolução CONAMA nº 357, de 17 de março de 2005. Dispõe sobre a classificação dos corpos de água e diretrizes ambientais para o seu enquadramento, bem como estabelece as condições e padrões de efluentes, e dá outras providencias. Diário Oficial da República Federativa do Brasil [online], Brasília, 18 mar. pp. 58-63. Available from: http://www.mma.gov.br/port/conama/res/res05/res35705.pdf
BOURRACHOT, O.; SIMON, R.; GILBIN, R. The effects of waterborne uranium on the hatching success, development, and survival of early life stages of zebrafish (Danio rerio). Aquatic Toxicology, v. 90, p. 29- 36, 2008.
BOURRACHOT, S.; BRION, F.; PEREIRA, S.; FLORIANI, M.; CAMILLERI, V.; CAVALIÉ, I.; PALLUEL, O.; ADAM- GUILLERMIN, C. Effects of depleted uranium on the reproductive success and F1 generation survival of zebrafish (Danio rerio). Aquatic Toxicology, v. 154, p. 1-11, 2014.
CAZAN, A.M.; KLERKS, P.L. Effects from a short-term exposure to copper or cadmium in gravid females of the livebearer fish (Gambusia affinis). Ecotoxicology and Environmental Safety, v. 118, p. 199-203, 2015.
CHEN, L.; WANG, X.; ZHANG, X.; LAM, P.K.S.; GUO, Y.; LAM, J.C.W.; ZHOU, B. Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution, v. 230, p. 96- 106, 2017.
CHOE, S.Y.; KIM, S.J.; KIM, H.G.; LEE, J.H.; CHOI, Y.; LEE, H.; KIM, Y. Evaluation of estrogenicity of major heavy metals. Science of The Total Environment, v. 312, v. 1-3, p. 15-21, 2003.
CHOUCHENE, L.; BANNI, M.; KERKENI, A.;SAID, K.; MASSAOUDI, I. Cadmium-induced ovarian pathophysiology is mediated by change in gene expression pattern of zinc transporters in zebrafish (Danio rerio). Chemico-Biological Interactions, v. 193, n. 2, p. 172-179, 2011.
DALZOCHIO, T.; GOLDONI, A.; RODRIGUES, G.Z.P.; PETRY, I.E.; SILVA, L.B.; GEHLEN, G. Gill histopathology and micronucleus test of Astyanax jacuhiensis (Cope, 1894) (Teleostei, Characidae) to evaluate effects caused by acute exposure to aluminum. Biotemas, v. 29, n. 1, p. 75-83, 2016.
DALZOCHIO, T.; RODRIGUES, G.Z.P.; SIMÕES, L.A.R.; SOUZA, M.S.; PETRY, I.E.; ANDRIGUETTI, N.B.; SILVA, G.J.H.; SILVA, L.B.; GEHLEN, G. In situ monitoring of the Sinos River, southern Brazil: water quality parameters, biomarkers, and metal bioaccumulation in fish. Environmental Science and Pollution Research, v. 25, n. 10, p. 9485-9500, 2018.
DARBRE, P.D. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. Journal of Applied Toxicology, v. 26, p. 191-197, 2006.
DRIESSNACK, M.K.; MATTHEWS, A.L.; RAINE, J.C.; NIYOGI, S. Interactive effects of chronic waterborne copper and cadmium exposure on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Comparative Biochemistry and Physiology, Part C, v. 179, p. 165- 173, 2016.
DRIESSNACK, M.K.; JAMWAL, A.; NIYOGI, S. Effects of chronic waterborne cadmium and zinc interactions on tissuespecific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Ecotoxicology and Environmental Safety, v. 140, p. 65- 75, 2017.
Environmental Protection Agency (EPA). Special report on environmental endocrine disruption: an effects assessment and analysis. Washington, DC: US Environmental Protection Agency; 1997
GARCIA-MORALES, P.; SACEDA, M.; KENNEY, N.; KIM, N.; SALOMON, D.S.; GOTTARDIS, M.M.; SOLOMON, H.B.; SHOLLER, P.F.; JORDAN, V.C.; MARTIN, M.B. Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J. Biol. Chem., v. 269, n. 24, p. 16896- 16901, 2003.
GÁRRIZ, A.; DEL FRESNO, P.S.; CARRIQUIRIBOR, P.; MIRANDA, L.A. Effects of heavy metals identified in Chascomús shallow lake on the endocrine-reproductive axis of pejerrey fish (Odontesthes bonariensis). Gen Comp Endocrinol, v. 22, 2018.
GOMBEAU, K.; BOURDINEAUD, J.P.; RAVANAT, J.L.; ARMANT, O.; CAMILLERI, V.; CAVALIE, I.; FLORIANI, M.; GUILLERMIN-ADAM, C. A. Epigenetic, histopathological and transcriptomic effects followingexposure to depleted uranium in adult zebrafish and their progeny. Aquatic Toxicology, v. 184, p. 14-25, 2017.
GUCHHAIT, R.; CHATTERJEE, A.; GUPTA, S.; DEBNATH, M.; MUKHERJEE, D.; PRAMANICK, K. Molecular mechanism of mercury-induced reproductive impairments in banded gourami, Trichogaster fasciata. General and Comparative Endocrinology, v. 255, p. 40- 48, 2018.
HU, Q.; ZHU, S. Induction of chromosomal aberrations in male mouse germ cells by uranyl fluoride containing enriched uranium. Mutat Res, v. 244, p. 209–14, 1990.
ISMAIL, N.A.H.; WEE, S.Y.; ARIS, S.Z. Multi-class of endocrine disrupting compounds in aquaculture ecosystems and health impacts in exposed biota. Chemosphere, v. 188, p. 375- 388, 2017.
JAMES, R.; SAMPATH, K.; JOTHILAKSHMI, S.; VASUDHEVAN, I.; THANGARATHINAM, R. Effects of copper toxicity on growth, reproduction and metal accumulation in chosen ornamental fishes. Ecohydrology e Htdrobiology, v. 8, p. 89 -97, 2008.
LI, D.; LU, C.; WANG, J.; HU, W.; CAO, Z.; SUN, D.; XIA, H.; MA, X. Developmental mechanisms of arsenite toxicity in zebrafish (Danio rerio) embryos. Aquatic Toxicology, v. 91, p. 229- 237, 2009.
KIDA, B.M.S.; ABDALLA, R.P.; MOREIRA, R.G. Effects of acidic water, aluminum, and manganese on testicular steroidogenesis in Astyanax altiparanae. Fish Physiol Biochem, v. 42, p. 1347- 1356, 2016.
LASKEY, J.W.; PHELPS, P.V. Effect of cadmium and other metal cations on in vitro Leydig cell testosterone production. Toxicol. Appl. Pharmacol., v. 108, n. 2, p. 296- 306, 1991.
LEVADOUX, Y.E.; FRELON, S.; SIMON, O.; ARNAUDGUILHEM, C.; LOBINSKI, R.; MOUNICOU, S. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Metallomics, v. 9, 2017.
LLOBET, J.M.; SIRVENT, J.J.; ORTEGA, A.; DOMINGO, J.L. Influence of chronic exposure to uranium on male reproduction in mice. Fundam Appl Toxicol, v. 16, p. 821–9, 1991.
MACHADO, C.S.; FREGONESI, B.M.; ALVES, R.I.S.; TONANI, K.A.A.; SIERRA, J.; MARTINIS, B.S.; CELERE, B.S.; MARI, M.; SCHUHMACHER, M.; NADAL, M.; DOMINGO, J.L.; SEGURA-MUÑOZ, S. Health risks of environmental exposure to metals and herbicides in the Pardo River, Brazil. Environmental Science and Pollution Research, v. 24, n. 25, p. 20160-20172, 2017.
MALVANDI, H. Preliminary evaluation of heavy metal contamination in the Zarrin- Gol River sediments, Iran. Mar. Pollut. Bull., v. 117, p. 547-533, 2017.
MARTIN, M.B.; REITER, R.; PHAM, T.; AVELLANET, Y.R.; CAMARA, J.; LAHM, M.; PENTECOST, E.; PRATAP, K.; GILMORE, B.A.; DIVEKAR, S.; DAGATA, R.S.; BULL, J.L.; STOICA, A. Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology, v. 144, n. 6, p. 2425- 2436, 2003.
MONNERET, C. What is an endocrine disruptor? C R Biol., v. 340, n. 9-10, p. 403- 405, 2017.
NABINGER, D.D.; ALTENHOFEN, S.; BITENCOURT, P.E.R.; NERY, L.R..; LEITE, C.E.; VIANA, M.R.M.R.; BONAN, C.D. Nickel exposure alters behavioral parameters in larval and adult zebrafish. Sci Total Environ, v. 15, p. 1623- 1633, 2018.
PASCHOALINI, A.L.; SAVASSI, L.A.; ARANTES, F.P.; RIZZO, E.; BAZZOLI, N. Heavy metals accumulation and endocrine disruption in Prochilodus argenteus from a polluted neotropical river. Ecotoxicology and Environmental Safety, v. 169, p. 539-550, 2019.
PIASEK, M.; BLANUSA, M.; KOSTIAL, K.; LASKEY, J.W. Placental cadmium and progesterone concentrations in cigarette smokers. Reprod Toxicol v. 15, p. 673–681, 2001.
REINARDY, H.C.; SYRETT, J.R.; JEFFREE, R.S.; HENRY, T.B.; JHA, A.N. Cobalt-induced genotoxicity in male zebrafish (Danio rerio), with implications for reproduction and expression of DNA repair genes. Aquatic Toxicology, v. 126, p. 224- 230, 2013.
SAFE, S. Cadmium's disguise dupes the estrogen receptor. Nature Medicine, v. 9, p. 1000-01, 2003.
SENGER, M.R.; RICO, E.P.; ARIZI, M.B.; FRAZZON, A.P.G.; DIAS, R.D.; BOGO, M.R.; BONAN, C.D. Exposure to Hg2+ and Pb2+ changes NTPDase and ecto-5′-nucleotidase activities in central nervous system of zebrafish (Danio rerio). Toxicology, v. 226, n. 2-3, p. 229-237, 2006.
SEGNER, H. Reproductive and developmental toxicity in fishes. In: Reproductive and Developmental Toxicology. Gupta, R.C. Elsevier, 2011, 1243 p.
SIMON, O.; FLOCH, E.; GEFFROY, B.; FRELON, S. Exploring ecotoxicological fish bioassay for the evaluation of uranium reprotoxicity. Environmental Toxicology, v. 33, n. 8, p. 1817- 1824, 2014.
SIMON, O.; GAGNAIRE, B.; CAMILLERI, V.; CAVALIÉ, I.; FLORIANI, M.; GUILLERMIN, C.A. Toxicokinetic and toxicodynamic of depleted uranium in the zebrafish, Danio rerio. Aquatic Toxicology, v. 197, p. 9-18, 2018.
SPERANZA, A.W.; SELEY, R.J.; SELEY, V.A.; PERMUTTER, A. The effect of sublethal concentrations of zinc on reproduction in the zebrafish, Brachydanio rerio Hamilton-Buchanan. Environmental Pollution, v. 12, 1977.
STOICA, A.; KATZENELLENBOGEN, B.S.; MARTIN, M.B. Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol. Endocrinol., v. 14, n. 4, p. 545- 553, 2000.
TILTON, S.C.; FORAN, C.M.; BENSON, W.H. Effects of cadmium on the reproductive axis of Japanese medaka (Oryzias latipes). Comp. Biochem. Phys., v. 136C, p. 265- 276, 2003.
THOMAS, P.; KHAN, I.A. Mechanisms of chemical interference with reproductive endocrine function in sciaenid fishes. Chemically induced alterations in functional development and reproduction of fishes, v. 29, 1997.
URIEN, N.; COOPER, S.; CARON, A.; SONNENBERG, H.; ROZON-RAMILO, L.; CAMPBELL, P.C.G.; COUTURE, P. Subcellular partitioning of metals and metalloids (As, Cd, Cu, Se and Zn) in liver and gonads of wild white suckers (Catostomus commersonii) collected downstream from a mining operation. Aquatic Toxicology, v. 202, p. 105-116, 2018.
VERGILIO, C.S.; MOREIRA, R.V.; CARVALHO, C.E.V.; MELO, E.J.T. Evolution of cadmium effects in the testis and sperm of the tropical fish Gymnotus carapo. Tissue and Cell, v. 47, n. 2, p. 132-139, 2015.
WANG, P.; DU, Z.; GAO, S.; ZHANG, X.; GIESY, J.P. Impairment of reproduction of adult zebrafish (Danio rerio) by binary mixtures of environmentally relevant concentrations of triclocarban and inorganic mercury. Ecotoxicology and Environmental Safety, v. 134, p. 124 – 132,2016.
WANG, X.; ZENG, Y.X.; ZHAO, H.; CAO, J.; JIANG, W. Effects of chlorogenic acid against aluminium neurotoxicity in ICR mice through chelation and antioxidant actions. Journal of Functional Foods, v. 40, p. 365-376, 2018.
WILSON, V.S.; BOBSEINE, K.; GRAY JR, L.E. Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists. Toxicol. Sci., v. 81, n. 1, p. 69-77, 2004.
WU, S.M.; TSAI, P.J.; CHOU, M.Y.; WANG, W.D. Effects of Maternal Cadmium Exposure on Female Reproductive Functions, Gamete Quality, and Offspring Development in Zebrafish (Danio rerio). Arch Environ Contam Toxicol, v. 65, p. 521- 536, 2013.
ZHANG, J.; YANG, Y.; LIU, W.; LIU, J. Potential endocrine-disrupting effects of metals via interference with glucocorticoid and mineralocorticoid receptors. Environmental Pollution, v. 242, p. 12-18, 2018.
ZHAO, Y.Q.; LIU, G.D.; HOU, C.C.; HAN, Y.L.; ZHU, J.Q. Effect of cadmium exposure on antioxidant enzyme catalase in different tissues of Acrossocheilus fasciatus. Mol Cell Toxicol, v. 12, p. 255- 263, 2016.
ZHENG, J.L.; YUAN, S.S.Y.; WU, C.W.; LV, Z.M. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquatic Toxicology, v. 180, p. 36-44, 2016.
ZHU, S.P.; HU, Q.Y.; LUN, M.Y. Studies on reproductive toxicity induced by enriched uranium. Zhonghua Yu Fang Yi Xue Za Zhi, v. 28, p. 219- 22, 1994.
ZHENG, R.; ZHANG, Y.; FANG, C.; CHEN, M.; HONG, F.; BO, J. Joint effects of chronic exposure to environmentally relevant levels of nonylphenol and cadmium on the reproductive functions in male rockfish Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 215, p. 25- 32, 2019.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
As Políticas Culturais em Revista aplica a Licença Creative Commons Atribuição-Não Comercial 4.0 Internacional (CC BY-NC-SA 4.0) para os trabalhos que publica. Esta licença foi desenvolvida para facilitar o acesso aberto - ou seja, o acesso livre, imediato, e a reutilização irrestrita de trabalhos originais de todos os tipos. Nossos autores mantêm os direitos autorais mas, sob essa licença, concordam em deixar os artigos legalmente disponíveis para reutilização, sem necessidade de permissão ou taxas, para praticamente qualquer finalidade. Qualquer pessoa pode copiar, distribuir ou reutilizar esses artigos, desde que o autor e a fonte original (Políticas Culturais em Revista) sejam devidamente citados.
