Atividade dos genes relacionados à pluripotência em ovinos

Autores

  • Priscila Germany Côrrea Silva Universidade Federal Rural de Pernambuco (UFRPE)
  • Marcelo Tigre Moura Universidade Federal Rural de Pernambuco (UFRPE)
  • Valeska Andrea Ático Braga Universidade Federal Rural de Pernambuco (UFRPE)
  • José Carlos Ferreira Silva Universidade Federal Rural de Pernambuco (UFRPE)
  • Pabola Santos Nascimento Universidade Federal Rural de Pernambuco (UFRPE)
  • Ludymila Furtado Cantanhêde Universidade Federal Rural de Pernambuco (UFRPE)
  • Maiana Silva Chaves Universidade Federal Rural de Pernambuco (UFRPE)
  • Marcos Antonio Lemos Oliveira

DOI:

https://doi.org/10.26605/medvet-n2-1745

Palavras-chave:

Ovis aries, totipotência, embriogênese, embriologia

Resumo

Embriões antes da implantação possuem células pluripotentes, ou seja, células que apresentam a capacidade de se diferenciar em todos os tecidos que compõem o feto. O controle da pluripotência em nível molecular é estabelecido por diversos fatores, entre eles, os genes relacionados à pluripotência (GRPs). Estes genes contribuem para inibição do processo de diferenciação celular e manutenção da viabilidade de células pluripotentes. No entanto, apesar do crescente conhecimento sobre as funções dos GRPs em camundongos e humanos, pouco se conhece sobre a expressão espaço-temporal e funções dos GRPs em outras espécies, incluindo ovinos. Evidências em bovinos, humanos e camundongos demonstram que GRPs podem apresentar mecanismos de ação diferentes entre as espécies. O objetivo da revisão foi analisar a atividade dos GRPs em ovinos através do perfil de expressão espaço-temporal e funções, bem como apresentar alternativas para acelerar o entendimento da pluripotência na espécie.

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Publicado

13-12-2017

Como Citar

Silva, P. G. C., Moura, M. T., Braga, V. A. Ático, Silva, J. C. F., Nascimento, P. S., Cantanhêde, L. F., Chaves, M. S., & Oliveira, M. A. L. (2017). Atividade dos genes relacionados à pluripotência em ovinos. Medicina Veterinária, 11(2), 127–136. https://doi.org/10.26605/medvet-n2-1745

Edição

v. 11 n. 2 (2017)

Seção

Reprodução Animal

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