Atividade dos genes relacionados à pluripotência em ovinos
DOI:
https://doi.org/10.26605/medvet-n2-1745Keywords:
Ovis aries, totipotência, embriogênese, embriologiaAbstract
Embriões antes da implantação possuem células pluripotentes, ou seja, células que apresentam a capacidade de se diferenciar em todos os tecidos que compõem o feto. O controle da pluripotência em nível molecular é estabelecido por diversos fatores, entre eles, os genes relacionados à pluripotência (GRPs). Estes genes contribuem para inibição do processo de diferenciação celular e manutenção da viabilidade de células pluripotentes. No entanto, apesar do crescente conhecimento sobre as funções dos GRPs em camundongos e humanos, pouco se conhece sobre a expressão espaço-temporal e funções dos GRPs em outras espécies, incluindo ovinos. Evidências em bovinos, humanos e camundongos demonstram que GRPs podem apresentar mecanismos de ação diferentes entre as espécies. O objetivo da revisão foi analisar a atividade dos GRPs em ovinos através do perfil de expressão espaço-temporal e funções, bem como apresentar alternativas para acelerar o entendimento da pluripotência na espécie.Downloads
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