Fluido oral: avanços tecnológicos e implicações clínicas na espécie suína
Keywords:
Bem-estar animal, diagnóstico, fluido oral, patógenos, suíno.Abstract
O interesse pelos métodos laboratoriais à base do fluido oral tem aumentado e os estudos apontam como uma alternativa nas análises sanguíneas e séricas. Diversos patógenos podem ser avaliados pela reatividade de proteínas e detecção de antígenos. Na espécie suína, em especial, o uso do fluido oral está ampliando as perspectivas de desenvolvimento e aplicação nos diagnósticos laboratoriais, monitoramentos de rebanho, bem como a avaliação do bem-estar animal. A proposta desta revisão é fazer uma abordagem sobre a colheita do fluido oral, o histórico e aplicações dos métodos laboratoriais, bem como a identificação dos patógenos, das imunoglobulinas, das proteínas e hormônios esteróides no fluido oral da espécie suína.Downloads
References
AMADO, L.A. et al. Detection of hepatitis A, B, and C virus-specific antibodies using oral fluid for epidemiological studies. Memorial do Instituto Oswaldo Cruz, v. 101, p. 149-155, 2006.
BABOL, J.; SQUIRES, E.J.; BONNEAU, M. Factors regulating the concentrations of 16-androstene steroids in submaxillary salivary glands of pigs. Journal of Animal Science, v. 74, p. 413-419, 1996.
BAPTISTA, R.I.A.A. Avaliação comportamental e fisiológica de suínos em baias individuais e gaiolas metabólicas. 2012. 144 f. Dissertação (Mestrado em Ciência Veterinária) - Programa de Pós-Graduação em Ciência Veterinária, Universidade Federal Rural de Pernambuco.
BAPTISTA, R.I.A.A.; BERTANI, G.R.; BARBOSA, C.N. Indicadores do bem-estar em suíno. Ciência Rural, v. 41, n. 10, p. 1823-1830, 2011.
BARBOSA, C.N. et al. Aplicação da metodologia de coleta do fluido oral em suínos mestiços. Medicina Veterinária, v. 7, n. 3, p. 32-38, 2013.
BRANDTZAEG, P. Do salivary antibodies reliably reflect both mucosal and systemic immunity? Annals of the New York Academy of Sciences, v. 1098, p.288-311, 2007.
BRANDTZAEG, P. Immunochemical comparison of proteins in human gingival pocket fluid, serum and saliva. Archives of Oral Biology, v. 10, n. 5, p. 795-802, 1965.
BUSHONG, D.M.; FRIEND, T.H.; KNABE, D. A. Salivary and plasma cortisol response to adrenocorticotropic administration in pigs. Laboratory Animals, v. 34, p. 171-181, 2000.
CASTRO, M.; MOREIRA, A.C. Análise crítica do cortisol salivar na avaliação do eixo hipotálamo-hipófise-adrenal. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 47, n. 4, p. 458-367, 2003.
CHALLACOMBE, S.J. et al. Passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys. Immunology, v. 35, p. 923-931, 1978.
COOK, C.J. et al. Hands-on and hands-off measurement of stress. In: MOBERG, G. P.; MENCH, J. A. The biology of animal stress: basic principles and implications for animal welfare. Wallingford: CAB International, 2000. Cap.6, p.123-146.
CORTHIER G. Swine fever: influence of passive immunity on pig immune response following vaccination with a live virus vaccine (Thiverval strain). Annals of Veterinary Research, v. 7, p. 361-372, 1976.
COSTA, G.; OLIVEIRA, S.; TORRISON, J. Detection of Actinobacillus pleuropneumoniae in oral-fluid samples obtained from experimentally infected pigs. Journal of Swine Health and Production, v. 20, n. 2, p. 78–81, 2012.
DALLA COSTA, O.A. et al. Tempo de jejum na granja sobre o perfil hormonal e os parâmetros fisiológicos em suínos de abate pesados. Ciência Rural, v. 38, n. 8, p. 2300-2306, 2008.
DeBUYSSCHER, E.; BERMAN, D. Secretory immune response in intestinal mucosa and salivary gland after experimental infection of pigs with transmissible gastro-enteritis virus. American Journal of Veterinary Research, v. 41, p. 1214–1220, 1980.
DeLIMA, A.J.; VAN DYKE, T.E. Origin and function of the cellular components in gingival crevice fluid. Periodontology 2000, v. 31, p. 55–76, 2003.
DETMER, S.E. et al. Detection of influenza a virus in porcine oral fluid samples. Journal of Veterinary Diagnostic Investigation, v. 23, p. 241-247, 2011.
EBLÉ, P.L. et al. Vaccination of pigs two weeks before infection significantly reduces transmission of foot-and-mouth disease virus. Vaccine, v. 22, p.1372-1378, 2004.
ESCRIBANO, D.; FUENTES-RUBIO, M.; CERON, J.J. Salivary testosterone measurements in growing pigs: validation of an automated chemiluminescent immunoassay and its possible use as an acute stress marker. Research in Veterinary Science, v. 97, n. 1, p. 20-25, 2014.
ESCRIBANO, D.; FUENTES-RUBIO, M.; CERÓN, J.J. Validation of an automated chemiluminescent immunoassay for salivary cortisol measurements in pigs. Journal of Veterinary Diagnostic Investigation, v. 24, p. 918-923, 2012.
FRANK SMITHIES, M.D. The glycyltryptophan (peptid) splitting agent in human saliva. The Archives of Internal Medicine, v. 10, n. 6, p. 521-533, 1912.
GIMÉNEZ-LIROLA, L.G. et al. Improving ante mortem diagnosis of Erysipelothrix rhusiopathiae infection by use of oral fluids for bacterial, nucleic acid, and antibody detection. Journal of Microbiological Methods, v. 92, p. 113-121, 2013.
GRANDIN, T.; JOHNSON, C. O bem-estar dos animais – Proposta de uma vida melhor para todos os bichos. São Paulo: Rocco, 2010. 334 p.
GROOPMAN, J.E. et al. HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science, v. 226, p. 447-449, 1984.
GUTIÉRREZ, A.M. et al. Circadian pattern of acute phase proteins in the saliva growing pigs. The Veterinary Journal, v. 196, n. 2, p. 167-170, 2013.
GUTIÉRREZ, A.M. et al. Proteomic analysis of porcine saliva. The Veterinary Journal, v. 187, p. 356-362, 2011.
GUTIÉRREZ, A.M. et al. Use of saliva for haptoglobin and C-reactive protein quantifications in porcine respiratory and reproductive syndrome affected pigs in field conditions. Veterinary Immunology and Immunopathology, v. 132, p. 218–223, 2009.
HELFAND, R.F. et al. Comparative detection of measles-specific IgM in oral fluid and serum from children by an antibody-capture IgM EIA. The Journal of Infectious Diseases, v.173, p.1470-1474, 1996.
HENLE, G. et al. Isolation of mumps virus from human beings with induced apparent or inapparent infection. The Journal of Experimental Medicine, v. 88, n. 2, p.223-232, 1948.
HILLMANN, E. et al. Effects of weight, temperature and behaviour on the circadian rhythm of salivary cortisol in growing pigs. Animal: an International Journal of Animal Bioscience, v. 2, p. 405-409, 2008.
HODINKA, R.L.; NAGASHUNMUGAM, T.; MALAMUD, D. Detection of human immunodeficiency virus antibodies in oral fluids. Clinical and Diagnostic Laboratory Immunology, v. 5, n. 4, p. 419–426, 1998.
HÖFLING, J.F.; GONÇALVES, R.B. Imunologia para odontologia. Porto Alegre: Artmed, 2007, 310 p.
HOWE, P.R. A study of the microörganisms of dental caries. The Journal of Medical Research, v. 36, n. 3, p. 481–492, 1917.
HUDMAN, D.B. et al. Digestive enzymes of the baby pig. Pancreatic and salivary amylase. Journal of Agricultural and Food Chemistry, v. 3, n. 9, p. 691-693, 1957.
HUMPHREY, S.P.; WILLIAMSON, R.T. A review of saliva: normal composition, flow, and function. The Journal of Prosthetic Dentistry, v.85, p.162–169, 2001.
JAY, D.C. et al. Effect of prenatal stress on subsequent response to mixing stress and a lipopolysaccharide challenge in pigs. Journal of Animal Science, v. 89, p. 1787-1794, 2011.
KATZ, F.H.; SHANNON, I.L. Identification and significance of parotid fluid corticosteroids. Acta Endocrinology, v. 46, p. 393-404, 1964.
KAUFMAN, E.; LAMSTER, I.B. The diagnostic applications of saliva – a review. Oral Biology & Medicine, v. 13, n. 2, p. 197-212, 2002.
KITTAWORNRAT, A. et al. Detection of porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in oral fluid specimens using a commercial PRRSV serum antibody enzyme-linked immunosorbent assay. Journal of Veterinary Diagnostic Investigation, v. 24, n. 2, p. 262-269, 2012.
KITTAWORNRAT, A. et al. Kinetics of the porcine reproductive and respiratory syndrome virus (PRRSV) humoral immune response in swine serum and oral fluids collected from individual boars. BMC Veterinary Research, v. 9, n. 61, p. 1-10, 2013.
MADAR, R.; STRAKA, S.; BASKA, T. Detection of antibodies in saliva - an effective auxiliary method in surveillance of infectious diseases. Bratislavské Lekárske Listy, v. 103, n. 1, p. 38-41, 2002.
MARTÍN, P. et al. Cortisol en saliva como indicador de estrés en porcino. Revista Complutense de Ciencias Veterinarias, v. 7, n. 1, p. 30-33, 2013.
MCKIE, A.; VYSE, A.; MAPLE, C. Novel methods for the detection of microbial antibodies in oral fluid. The Lancet. Infectious Diseases, v. 2, p. 18–24, 2002.
MESTECKY, J. et al. Mucosal Immunology. 3. ed. Amsterdam: Elsevier/Academic Press, 2005. 2064 p.
MORIYOSHI, M. et al. Early pregnancy diagnosis in the sow by saliva progesterone measurement using a bovine milk progestone qualitative test EIA kit. Journal of Veterinary Medical Science, v. 58, n. 8, p. 737-741, 1996.
MUR, L. et al. Potential use of oral fluid samples for serological diagnosis of African swine fever. Veterinary Microbiology, v.165, p.135–139, 2013.
NA-LAMPANG, P. Effects of methods of confinement during transportation of market pigs on their behavior, stress and injury. Songklanakarin Journal of Science and Technology, v. 5, n. 2, p. 137-141, 2013. NGOUNOU WETIE, A.G. et al. A pilot proteomic of salivary biomarkers in autism spectrum disorder. Autism Research, v. 8, n. 3, p. 338-350, 2015.
O’DRISCOLL, K. et al. The influence of a magnesium rich marine supplement on behaviour, salivary cortisol levels, and skin lesions in growing pigs exposed to acute stressors. Applied Animal Behaviour Science, v. 145, n. 3-4, p. 92, 2013.
PANYASING, Y. et al. Kinetics of influenza A virus nucleoprotein antibody (IgM, IgA, and IgG) in serum and oral fluid specimens from pigs infected under experimental conditions. Vaccine, v. 31, n. 52, p. 6210–6215, 2013.
PARROTT, R.F.; MISSON, B.H. Changes in pig salivary cortisol in response to transport simulation, food and water deprivation, and mixing. The British Veterinary Journal, v. 145, n. 6, p. 501-505, 1989.
PARROTT, R.F.; MISSON, B.H.; BALDWIN, B.A. Salivary cortisol in pigs following adrenocorticotrophic ormone stimulation: comparison with plasma levels. The British Veterinary Journal, v. 145, n. 4. p. 362-366, 1989.
PRICKETT, J.R. et al. Oral-fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections. Journal of Swine Health and Production, v. 1, p. 86-91, 2008.
PRICKETT, J.R. et al. Prolonged detection of PCV2 and anti-PCV2 antibody in oral fluids following experimental inoculation. Transboundary and Emerging Diseases, v. 58, n. 2, p. 121-127, 2011.
PRICKETT, J.R.; ZIMMERMAN, J.J. The development of oral fluid-based diagnostics and application in veterinary medicine. Animal Health Research Reviews, v. 11, n. 2, p. 207-216, 2010.
ROUX, M.N.; NOCARD. At what moment does the virus of rabies appear in the saliva of rabid animals? Journal of Comparative Pathology and Therapeutics. v. 3, p. 128-134, 1890.
SABIN, A.B.; WARD, R. The natural history of human poliomyelitis. The Journal of Experimental Medicine, v. 74, n. 6, p. 519-529, 1941.
SHAFIQ, N.; MALHOTRA, S. Use of antibiotics in community-acquired pneumonia. In: JINDAL, S. K.; GULERIA, R. World clinics pulmonary & critical care medicine: Pneumonias. Jaypee: Daryaganj, 2012. p. 95-116.
SHILITOE, E.J.; LENHER, T. Immunoglobulins and complement in crevicular fluid, serum and saliva in man. Archives of Oral Biology, v. 17, n. 2, p. 241–247, 1972.
SISSON, S.; GROSSMAN, J.D.; GETTY, R. Anatomy of the Domestic Animals. 5. ed. Philadelphia: Saunders, 1975, 2130p.
SOLER, L.; GUTIÉRREZ, A.; CERÓN, J.J. Serum amyloid A measurements in saliva and serum in growing pigs affected by porcine respiratory and reproductive syndrome in field conditions. Research in Veterinary Science, v. 93, n. 3, p.1266-1270, 2012.
STALLKNECHT, D.E. et al. Potential for contact and mechanical vector transmission of vesicular stomatitis virus New Jersey in pigs. American Journal of Veterinary Research, v. 60, p. 43-48, 1999.
SUGIMOTO, M. et al. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics, v. 6, p. 78-95, 2010.
VINNING, R.F. et al. Salivary cortisol: a better measure of adrenal cortical function than serum cortisol. Annals of Clinical Biochemistry, v. 20, n. 6, p. 329-335, 1983.
WARRENER, L.; SAMUEL, D. Evaluation of a commercial assay for the detection of mumps specific IgM antibodies in oral fluid and serum specimens. Journal of Clinical Virology, v. 35, p.130-134, 2006.
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