Indirect detection of respiratory viruses responsible for respiratory disease in sheep
DOI:
https://doi.org/10.26605/medvet-v14n1-2582Keywords:
bovine herpesvirus type-1, parainfluenza type -3, bovine respiratory syncytial virus, bovine viral diarrhea virus, serology.Abstract
Respiratory disease in sheep is an important disease in sheep flocks, in which viruses are categorized as primary etiological agents. It is responsible for elevated economic losses in sheep production and new data about its occurrence and the etiological agents are necessary to understand its situation in Brazilian flocks. This research aimed to detect antibodies against Bovine Viral Diarrhea Virus, Bovine Herpesvirus type 1, Bovine Respiratory Syncytial Virus (BRSV) and Bovine Parainfluenza type 3 (bPI-3) virus in healthy and pneumonic sheep in relation to clinical signs of respiratory disease. Ninety-nine male and female sheep from the states of São Paulo (SP) and Rio de Janeiro (RJ) were enrolled in this study. They were classified as healthy and pneumonic using physical examination. Serum samples were obtained, and they were used to determine the presence of antibodies against respiratory viruses using serum neutralization test. The association between the microorganisms, clinical status, and clinical signs of respiratory disease in sheep was evaluated. Antibodies against Bovine Parainfluenza type 3 virus were mainly detected (52.5%), followed by Bovine Respiratory Syncytial Virus (48.5%). Data analysis did not reveal any association between the presence of antibodies and clinical signs of respiratory disease in sheep. Respiratory disease is an important issue in sheep production in which different bacterial and viral etiologic agents may be involved in its development. BRSV and bPI-3 are circulating in sheep flocks from São Paulo and Rio de Janeiro.Downloads
References
Affonso, I.B.; Gatti, S.P.; Alexandrino, B.; Oliveira, M.C.; Medeiros, A.S.R.; Buzinaro, M.G.; Samara, S.I. Detection of antibodies against bovine respiratory syncytial virus (BRSV) in dairy cattle with different prevalences of bovine herpesvirus type-1 (BoHV-1) in São Paulo State, Brazil. Semina: Ciências Agrárias, 32(1): 295-299, 2011.
Autio, T.; Pohjanvirta, T.; Holopainen, R.; Rikula, U.; Pentikainen, J.; Huovilainen, A.; Rusanen, H.; Soveri, T.; Sihvonen, L.; Pelkonen, S. Etiology of respiratory disease in nonvaccinated, non-medicated calves in rearing herds. Veterinary Microbiology, 119: 256-265, 2007.
Belknap, E.B. Enfermidades do sistema respiratório. In: Pugh, D.G. (Ed). Clínica de ovinos e caprinos. 1a ed. São Paulo: Roca, 2005. p. 119-138.
Benesi, F.J.; Bertagnon, H.G.; Wachholz, L.; Leal, M.L.R.; Fernandes, W.R.; Benites, N.R.; Melville, P. Microbiota bacteriana e citologia da região traqueobrônquica de bezerros no período neonatal. Pesquisa Veterinária Brasileira, 33(6): 700-704, 2013.
Bosch, A.A.T.M.; Biesbroek, G.; Trzcinski, K.; Sanders, E.A.M.; Bogaert, D. Viral and bacterial interactions in the upper respiratory tract. PLos Pathogens, 49(1): e1003057, 2013.
Brown, T.T.; Ananaba, G. Effect of respiratory infections caused by bovine herpesvirus-1 or parainfluenza-3 virus on bovine alveolar macrophage functions. American Journal of Veterinary Research, 49(9): 1447-1451, 1988.
Bryson, D.G.; McNulty, M.S.; McCracken, R.M.; Cush, P.F. Ultrastructural features of experimental parainfluenza type 3 virus pneumonia in calves. Journal of Comparative Pathology, 93(3): 397-414, 1983.
Cabello, R.K.; Rivera, G. Frecuencia de los virus parainfluenza-3, respiratorio sincitial y diarrea viral bovina en un rebaño mixto de una comunidad campesina de Cusco. Revista de Investigaciones Veterinárias de Perú, 17(2): 167-172, 2006.
Caswell, J.L.; Williams, K. The respiratory system. In: Jubb, K.V.F.; Kennedy, P.C.; Palmer, N. (Ed.). Pathology of domestic animals. Edinburgh: Saunders Elsevier, 2007. p. 594-622.
Contreras-Luna, M.J.; Ramírez-Martínez, L.A.; Sarmiento Silva, R.E.; Cruz Lazo, C.; Pérez Torres, A.; Sánchez-Betancourt, J.I. Evidence of respiratory syncytial virus and parainfluenza-3 virus in Mexican sheep. Virus Disease, 28(1): 102-110, 2017.
Dal Pizzol, M.; Ravazzolo, A.P.; Fernandes, J.C.T.; Moojen, V. Detecção de anticorpos para o vírus Parainfluenza tipo 3 em bovinos e ovinos no Rio Grande do Sul, Brasil. Arquivos da Faculdade de Veterinária da UFRGS, 17: 59-64, 1989.
Gaeta, N.C.; Ribeiro, B.L.M.; Alemán, M.A.R.; Yoshihara, E.; Nassar, A.F.C.; Marques, E.C.; Timenetsky, J.; Gregory, L. Bacterial pathogens of the lower respiratory tract of calves from Brazilian rural settlement herds and their association with clinical signs of bovine respiratory disease. Pesquisa Veterinária Brasileira, 38(3): 374-381, 2018a.
Gaeta, N.C.; Ribeiro, B.L.M.; Alemán, M.A.R.; Yoshihara, E.; Marques, E.C.; Hellmeister, A.N.; Pituco, E.M.; Gregory, L. Serological investigation of antibodies against respiratory viruses in calves from Brazilian family farming and their relation to clinical signs of bovine respiratory disease. Pesquisa Veterinária Brasileira, 38(4): 642-648, 2018b.
Gonçalves, R.C. Semiologia do Sistema respiratório. In: Feitosa, F.L.F. Vete (Ed.). Semiologia veterinária: a arte do diagnóstico. 3a ed. São Paulo: Roca, 2014. p.313-331.
Gonçalves, R.C.; Silva, A.A.; Ferreira, D. Detection of serum antibodies to parainfluenza type 3 virus, respiratory syncytial virus, bovine viral diarrhea virus, and herpes virus type 1 in sheep in the Region of Botucatu, São Paulo. Brazilian Journal of Veterinary Medicine and Animal Health, 3(4): 1-5, 2011.
International Committee on Taxonomy of Viruses (ICTV). 2014. Available at: <https://talk.ictvonline.org/>. Accessed on: 10 jul. 2019.
Jehan, A.M. Isolation and Characterization of PI-3 Virus from Sheep and Goats. International Journal of Virology, 5(1): 28-35, 2009.
Lacasta, D.; Ferrer, L.M.; Ramos, J.J.; González, J.M.; De las Heras, M. Influence of climatic factors on the development of pneumonia in lambs. Small Ruminant Research, 80: 1-3, 2008.
Loken, T. Border disease in sheep. Veterinary Clinics of North America, 11: 579-595, 1995.
Mahdi, A.; Assel, A.; Haddel, B. A study of some pathological lesions in the lung of sheep in Duhok Abattoir. Journal of Veterinary Research, 14(2): 265-277, 2015.
Maiga, S.; Sarr, J. Epidemiological survey of the main respiratory viruses of small ruminants in Mali. Revenue D’Elevage et de Medicine Veterinarie Pays Tropicale, 45: 15-17, 1992.
Marcondes, J.S. Pesquisa de vírus relacionados com doenças respiratórias em ovinos sadios e naturalmente acometidos. 116p. Tese (Doutorado) - Faculdade de Medicina Veterinária e Zootecnia, campus Botucatu, Universidade Estadual Paulista, 2010.
Martin, W.B. Respiratory infections of sheep. Comparative Immunology Microbial Infectious Disease, 19(3): 171-179, 1996.
Navarro, T.; Ramos, J.J.; Ruíz de Arcaute, M.; González, J.M. Predisposing factors inducing ovine respiratory complex in intensive-reared lambs. Small Ruminant Research, 180: 106-111, 2019.
Pescador, C.A.; Corbellini, L.G.; Driemeier, D.; Gonçalves, R.K.; Cruz, C. Neurological disorder associated with Pestivirus infection in sheep in Rio Grande do Sul, Brazil. Ciência Rural, 34(3): 935-938, 2004.
Potgieter, L. Bovine viral diarrhea and mucosal disease. In: Coetzer, J.; Thomsom, N.G.R.; Tustin, R. (Ed.). Infectious diseases of livestock. 2nd ed. Cape Town: Oxford University Press, 2004. p. 946–969.
Radostits, O.M.; Blood, D.C.; Gay, C.C. Clínica Veterinária: um tratado de doenças dos bovinos, ovinos, suínos, caprinos e equinos. 9a ed. Rio de Janeiro: Guanabara Koogan, 2002.
Rusenova, N. Comparison of the seroprevalence against some respiratory viruses in mixed sheep-goat herds in two regions of Bulgaria. Trakia Journal of Science, 7(4): 58-62, 2009.
Saeed, K.I.; Ali, Y.H.; Taha, K.M.; Mohammed, N.E.; Nouri, M.N.; Mohammed, B.A.; Mohammed, O.I.; Elmagboul, S.B.; AlGhazali, F.A. Para influenza virus 3 infection in cattle and small ruminants in Sudan. Journal of Advances in Veterinary Animal Research, 3(3): 236, 2016.
Sharp, J.M.; Nettleton, P. Acute respiratory virus infections. In: Aitken, I. (Ed.). Diseases of sheep. 4th ed. Iowa: Blackwell Publishing Professional, 2007. p. 207–209.
Silva, T.L.A.; Oliveira, M.M.M.; Teixeira, M.N.; Mota, I.O.; Castro, R. Anticorpos anti pestivírus em caprinos e ovinos do sertão do estado de Pernambuco, Brasil. PUBVET, 10(2): 132-137, 2016.
Slauson, D.O.; Lay, J.C.; Castleman, W.L.; Neilsen, N.R. Alveolar macrophage phagocytic kinetics following pulmonary parainfluenza-3 virus infection. Journal of Leukocyte Biology, 41(5): 412-420, 1987.
Suresh, P.; Suribabu, T. Serological survey of bovine herpesvirus 1 (BHV-1) in sheep in Andha Pradesh. Indian Journal of Animal Science, 63: 146-147, 1993.
Tiwari, K.; Manning, S.H.; Meyer, K.; Ponce, C.; Deallie, C.; Thomas, D.; Sharma, R. Seroprevalence of antibodies to bovine herpes virus type-1 (BoHV-1) in ruminants of Grenada, West Indies. Journal of Animal Research, 6(6): 939-942, 2016.
Trueblood, M.S.; Swift, B.L.; Mcholland-Raymond, L. A bovine herpesvirus isolated from sheep. Canadian Journal of Comparative Medicine, 42(1): 97-99, 1978.
UNITED STATES DEPARTMENT OF AGRICULTURE (USDA). Code of Federal Regulation, Animal and plant health inspection service, title 9: Animals and animal products. Available at: <https://gov.ecfr.io/cgi-bin/retrieveECFR?gp=&SID=73970e074cf837bbda6af301a8dab4b2&pitd=20180101&n=pt9.1.113&r=PART&ty=HTML#se9.1.113_1309>. Accessed on: 10 jul. 2019.
Willoughby, R.; McKee, S.; Riddolls, L.; Vernaillen, C.; Dubovi, E.; Lein, D.; Mahony, J.B.; Chernesky, M.; Nagy, E. The effects of equine rhinovirus, influenza virus and herpesvirus infection on tracheal clearance rate in horses. Canadian Journal of Veterinary Research, 56(2): 115-121, 1992.
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