Síndrome Cardiorrenal tipo II: bases fisiopatológicas e terapêuticas em cães e gatos

Authors

  • Aline Nochi Berto Universidade de Marília (UNIMAR), Marília-SP, Brasil.
  • Beatriz Teixeira Martuchi Universidade de Marília (UNIMAR), Marília-SP, Brasil.
  • Luiz Otávio Rodrigues Ribeiro Universidade de Marília (UNIMAR), Marília-SP, Brasil.
  • Rodrigo Prevedello Franco Universidade de Marília (UNIMAR), Marília-SP, Brasil.

DOI:

https://doi.org/10.26605/medvet-v14n3-3870

Keywords:

insuficiência cardíaca, insuficiência renal, doença valvar crônica.

Abstract

A Síndrome Cardiorrenal (SCR) do tipo II é reconhecida por anormalidades crônicas da função cardíaca que promove lesão e disfunção renal. Nessa revisão de literatura será discutida a compreensão atual, mecanismos fisiopatológicos, aspectos etiológicos e clínicos, bem como a adequação terapêutica de cães e gatos acometidos pela síndrome cardiorrenal do tipo II. Devido à complexidade da síndrome, refletir sobre os diversos mecanismos fisiopatológicos torna-se essencial na continuidade de pesquisas em cães e gatos relacionadas ao diagnóstico precoce e, principalmente, pontos importantes a serem enfatizados no tratamento, com o intuito de obter melhores resultados na terapia de pacientes cardiorrenais.

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References

Acierno, M.J.; Brown, S.; Coleman, A.E.; Jepson, R.E.; Papich, M.; Stepien, R.L.; Syme, H.M. ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. Journal of Veterinary Internal Medicine, 32(6): 1803-1822, 2018.

Atkins, C.; Brown, W.A.; Coats, J.R.; Crawford, M.A.; DeFrancesco, T.C.; Edwards, J.; Fox, J.P.R.; Kenee, B.W.; Lehmkuhl, L.; Luethy, M.; Meurs, K.; Petrie, J.P.; Pipers, F.; Rosenthal, S.; Sidley, J.A.; Straus, J. Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation. Journal of the American Veterinary Medical Association, 221(5): 654-658, 2002.

Atkins, C.; Bonagura, J.; Ettinger, S.; Fox, P.; Gordon, S.; Haggstrom, R.; Hamlin, R.; Keene, B.; Luis-Fuentes, V.; Stepien, R. Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. Journal of Veterinary Internal Medicine, 23(9): 1142-1150, 2009.

Bartges, J.W. Chronic kidney disease in dogs and cats. The Veterinary Clinics of North America: Small Animal Practice, 42(4): 669-92, 2012.

Bonagura, J.D.; Bussadori, C.; Church, D. Recommendations for the diagnosis of heart disease and the treatment of heart failure in small animals. In: Miller, M.S.; Tilley, L.P.W.B. Manual of Canine and Feline Cardiology. Philadelphia: Saunders, 1995. p. 469-490.

Bragato, N.; Borges, N.C.; Fioravanti, M.C.S. B-mode and Doppler ultrasound of chronic kidney disease in dogs and cats. Veterinary Research Communications, 41(4): 307-315, 2017.

Carubelli, V.; Metra, M.; Lund, L.H. Negotiating renal dysfunction when treating patients with heart failure. Expert Review of Cardiovascular Therapy, 16(2): 113-122, 2018.

Chalhoub, S.; Langston, C.E.; Farrelly, J. The use of darbepoetin to stimulate erythropoiesis in anemia of chronic kidney disease in cats: 25 cases. Journal of Veterinary Internal Medicine, 26(6): 363-369, 2012.

Chamas, P.P.; Saldanha, I.R.; Costa, R.L. Prevalência da doença degenerativa valvar crônica mitral em cães. Journal of the Health Sciences Institute, 29(3): 214-217, 2011.

Chawla, L.S.; Herzog, C.A.; Costanzol, M.R.; Tumlin. J.; Kellum, J.; McCullough, P.; Ronco, C. Proposal for a functional classification system of heart failure in patients with end-stage renal disease: Proceedings of the Acute Dialysis Quality Initiative (ADQI) XI workgroup. Journal of the American College of Cardiology, 63(13): 1246-1252, 2014.

Davis, H.; Jensen, T.; Johnson, A.; Knowles, P.; Meyer, R.; Rucinsky, R.; Shafford, H. 2013 AAHA/AAFP fluid therapy guidelines for dogs and cats. Journal of the American Animal Hospital Association, 49(10): 149-159, 2013.

Dutton, E.; López-Alvarez; J. An update on canine cardiomyopathies – is it all in the genes? Journal of Small Animal Practice, 59 (11): 455-464, 2018.

Feijó, D.V.S.; Finato, R.B.; Fernandez, S.; Dan De Nardo, C.D.; Salvador, R.L.C.; Galvão, A.L.B. Diagnóstico e opções terapêuticas no controle da hipertensão arterial sistêmica em pequenos animais. Investigação, 15(1): 26-36, 2016.

Ferasin, L.; Sturgess, C.P.; Cannon, M.J.; Caney, S.M.; Gruffydd-Jones, T.J.; Wotton, P.R. Feline idiopathic cardiomyopathy: a retrospective study of 106 cats (1994-2001). Journal of Feline Medicine and Surgery, 5(8): 151-159, 2003.

Fiocchi, E.H.; Cowgill, L.D.; Brown, D.C.; Markovich, J.E.; Tucker, S.; Labato, M.A.; Callan, M.B. The use of darbapoetin to stimulate erythropoiesis in the treatment of anemia of chronic kidney disease in dogs. Journal of Veterinary Internal Medicine, 31(2): 476-485, 2017.

Freitas, G.C.; Veado, J.C.; Carregaro, A.B. Testes de avaliação de injúria renal precoce em cães e gatos. Semina: Ciências Agrárias, 35(1): 411-426, 2014.

Freitas, R.A.; Silva B.S.; Athar, C.V.; Marinho J.P.; Veiga, C.C.; Paiva, J.P. Estadiamento da doença renal crônica em cães domésticos com doença valvar crônica. Revista Brasileira de Medicina Veterinária, 38(2): 31-39, 2016.

Grande, D.; Gioia, M.I.; Terlizzese, P.; Iacoviello, M. Heart Failure and Kidney Disease. Advances in Experimental Medicine and Biology, 1067(19): 219-238, 2017.

Grauer, G.F. Diagnosis, management of hypertension, proteinuria in dogs with chronic renal disease. DVM Newsmagazine, 2009. Disponível em: <http://veterinarynews.dvm360.com/diagnosis-management-hypertension-proteinuria-dogs-with-chronic-kidney-disease>. Acesso em: 10 Abr. 2018.

Hall, J.A.; Yerramilli, M.; Obare, E.; Yerramilli, M.; Almes, K.; Jewell, D.E. Serum concentrations of Symmetric Dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. Journal of Veterinary Internal Medicine, 30(3): 794-802, 2016.

Hsueh, C.; Chen, N.; Lin, S.; Chen, P.; Gattone, V.; Allen, M.; Fishbein, M.; Moe, S. Pathogenesis of Arrhythmias in a Model of CKD. American Society of Nephrology, 25(12): 2812-2821, 2014.

IRIS. International Renal Interest Society. Staging Chronic Kidney Disease (CKD). 2013. Disponível em: <http://www.iriskidney.com/pdf/IRISposter.pdf >. Acesso em: 14 Jul. 2018.

Jacob, F.; Polzin, D.J.; Osborne, C.A.; Neaton, J.D.; Lekcharoensuk, C.; Allen, T.A.; Kirk, C.A.; Swanson, L.L. Association between initial systolic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure. Journal of the American Veterinary Medical Association, 222(3): 322-329, 2003.

Jois, P.; Mebazaa, A. Cardio-renal syndrome type 2: epidemiology, pathophysiology, and treatment. Seminars in Nephrology, 32(1): 26-30, 2012.

Langston, C. Managing fluid and electrolyte disorders in kidney disease. Veterinary Clinics of North America: Small Animal Practice, 47(2): 471-490, 2017.

Lee, Y.J.; Hu, Y.Y.; Lin, Y.S, Wong, M.; Kuo-Hsuan, H.; Hsu, W. Urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute canine kidney injury. BMC Veterinary Research, 8(248): 1-9, 2012.

Martins, H.; Pedro, N.; Castellano, M., Monteiro, P., Moura, J.J., Providência, L.A. Síndrome cardio-renal: Os desafios no tratamento da insuficiência cardíaca. Acta Médica Portuguesa, 24(7): 285-292, 2011.

Medeiros, A; Bacurau, A.V.N.; Vanzelli, A.S.; Rolim, N.P.L.; Brum, P.C. Sistema nervoso simpático na insuficiência cardíaca: ênfase na sinalização adrenérgica cardíaca. Revista Hipertensão, 12(3): 84-94, 2009.

Mora, S.D.; Dávila, E.Z.; Silva, E.N.; Mesquita, E.T., Martins, W.A.; Junior, H.V. Síndrome cardiorrenal tipo 1: Mecanismos fisiopatológicos e papel dos novos biomarcadores. Insuficiência Cardíaca, 11(1): 23-30, 2016.

Oliveira, P.; Domenech, O.; Silva, J.; Vannini, S.; Bussadori, R.; Bussadori, C. Retrospective Review of Congenital Heart Disease in 976 Dogs. Journal of Veterinary Internal Medicine, 25(3): 477-483, 2011.

Oliveira, F.M.; Santos, E.A.; Reis, A.C.; Feitosa, C.S.; Cerqueira, H.D.B.; Aptekmann, K.P. Ecocardiografia em cães com doença crônica de valva mitral: revisão de literatura. Tópicos especiais em Ciência Animal, 6(11): 158-171, 2017.

Orvalho, J.S.; Cowgill, L.D. Cardiorenal syndrome: diagnosis and management. Veterinary Clinics of North America: Small Animal Practice, 47(5): 1083-1102, 2017.

Palazzuoli, A.; Ronco, C. Cardio-renal syndrome: An entity cardiologists and nephrologists should be dealing with collegially. Heart Failure Reviews, 16(6): 503-508, 2011.

Palazzuoli, A.; Mccullough, P.A.; Ronco, C.; Nuti, R. Kidney disease in heart failure: the importance of novel biomarkers for type 1 cardio-renal syndrome detection. Internal and Emergency Medicine, 10(5): 543-554, 2015.

Peddle, G.D.; Singletary, G.E.; Reynolds, C.A.; Trafny, D.J.; Machen, M.C.; Oyama, M.A. Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease. Journal of Veterinary Cardiology, 14(1): 253-259, 2012.

Polzin, D.J. Evidence-based step-wise approach to managing chronic kidney disease in dogs and cats. Journal of Veterinary Emergency and Critical Care, 23(2): 205-215, 2013.

Ponikowski, P.; Voors, A.; Anker, S.; Bueno, H.; Cleland, J.; Coats, A.; Falk, V.; González-Juanatey, J.; Harjola, P.; Jankowska, E.; Jessup, M.; Linde, C.; Nihoyannopoulos, P.; Parissis, J.; Pieske, B.; Riley, J.; Rosano, G.; Ruilope, L.; Ruschitzka, F.; Rutten, F.; Van der Meer, P. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure, 37(27): 2129-2200, 2016.

Pouchelon, J.; Atkins, C.; Bussadori, C.; Oyama, M.; Vaden. S.; Bonagura, J.; Chetboul, V.; Elliot, J.; Francey, T.; Grauer, G.; Fuentes, V.; Moise, N.; Polzin, D.; Van Dongen, A.; Van Israel, N. Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement. Journal of Small Animal Practice, 56(9): 537-552, 2015.

Prowle, J.R.; Bellomo, R. Fluid administration and the kidney. Current Opinion in Critical Care, 19(4): 308-314, 2013.

Rossi, G.; Bertazzolo, W.; Binnella, M.; Scarpa, P.; Paltrinieri, S. Measurement of proteinuria in dogs: analytic and diagnostic differences using 2 laboratory methods. Veterinary Clinical Pathology, 45(3): 450-458, 2016.

Ronco, C.; Mccullough, P.; Anker, S.D.; Anand, I.; Aspromonte, N.; Bagshaw, S.; Bellomo, R.; Berl, T.; Bobek, I.; Cruz, D.; Daliento, L.; Davenport, A.; Haapio, M.; Hillege, H.; House, A.; Katz, N.; Maisel, A.; Mankad, S., Zanco, P.; Mebazaa, A.; Palazzuoli, A.; Ronco, F.; Shaw, A.; Sheinfeld, G.; Soni, S.; Vescovo, G.; Zamperetti, N.; Ponikowski, P. Cardio-renal Syndromes: report from the consensus conference of the Acute Dialysis Quality Initiative. European Heart Journal, 31(6): 703-711, 2010.

Ronco, C.; Di Lullo, L. Cardiorenal syndrome in western countries: Epidemiology, diagnosis and management approaches. Kidney Diseases, 2(4): 151-163, 2017.

Sarraf, M; Masoumi, A; Schrier, R.W. Cardiorenal Syndrome in Acute Decompensated Heart Failure. Journal of the American Society of Nephrology, 4(12): 2013-2026, 2009.

Shah, B.N.; Greaves, K. The cardiorenal syndrome: a review. International Journal of Nephrology, 2011(11): 1-11, 2011.

Shrestha, H.K.; Beg, M.A.; Siddiqui, M.A.R. Dynamic progesterone responses to stimulation of a natural pulse of a metabolite of prostaglandin F2α in heifers. Animal Reproduction Science, 118(5): 118-123, 2010.

Souza, W.N.; Araújo, C.M.; Silva, S.A.; Petribú, M.M. Anemia, disfunção renal e desnutrição associadas à insuficiência cardíaca em pacientes valvopatas. Arquivos Brasileiros de Cardiologia, 94(6): 794-798, 2010.

Strunz, C.M.; Marcondes-Santos, M.; Takada, J.Y.; Fragata, F.S.; Mansur, A.P. Escore de qualidade de vida como preditor de mortalidade em cães com doença degenerativa da valva mitral. Arquivos Brasileiros de Cardiologia, 108(7): 347-353, 2017.

Tidholm, A.; Ljungvall, I.; Michal, J.; Haggstrom, J.; Hoglund, K. Congenital heart defects in cats: a retrospective study of 162 cats (1996 e 2013). Journal of Veterinary Cardiology, 17(4): 215-219, 2015.

Yu, I.B.; Huang, H.P. Prevalence and prognosis of anemia in dogs with degenerative mitral valve disease. BioMed Research International, 2016(5): 1-5, 2016.

Published

2020-10-20

How to Cite

Berto, A. N., Martuchi, B. T., Ribeiro, L. O. R., & Franco, R. P. (2020). Síndrome Cardiorrenal tipo II: bases fisiopatológicas e terapêuticas em cães e gatos. Medicina Veterinária, 14(3), 162–172. https://doi.org/10.26605/medvet-v14n3-3870

Issue

Section

Small Animal Clinic and Surgery